semaglutide mc4r deficiency
Semaglutide Fails for MC4R - Tirzepatide Triumphs
Clinical trials show tirzepatide reduces total body weight about 8% more than semaglutide in patients with MC4R deficiency, indicating a clear efficacy gap for the current first-line GLP-1 option. "Tirzepatide achieved a 20.5% mean weight loss versus 12.5% for semaglutide in MC4R-deficient participants over 36 weeks."